Individuals with subjective cognitive impairment exhibit elevated levels of TNF-α, which are negatively correlated with β amyloid-42
Sara Serafini, Gabriella Ferretti, Paola Monterosso, Antonella Angiolillo, Alfonso Di Costanzo, Carmela Matrone · FENS Forum 2024
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and inability to perform daily activities. Recent research has implicated tumor necrosis factor-alpha (TNF-α) in the pathogenesis of AD. Elevated levels of TNF-α have been detected in the blood of patients with AD, and TNF-α has been observed in amyloid beta (Aβ) plaques. Despite the promising results from preclinical studies, the efficacy of TNF-α blockade as a therapeutic strategy for AD remains controversial. However, it remains unclear whether and how TNF-α influences the amyloidogenic p
ePoster · Neuroscience