Unlocking the potential of SVZ-derived oligodendrocytes through BDNF and adenosine A2AR modulation
Joana Mateus, João B Moreira, Andreia Barateiro, Diogo M Lourenço, Ana M Sebastião, Adelaide Fernandes, Sara Xapelli · FENS Forum 2024
Oligodendrocytes (OLs) are the myelin-forming cells in the Central Nervous System of vertebrates. The role of Adenosine A2A receptors (A2ARs) and brain-derived neurotrophic factor (BDNF) on adult oligodendrogenesis from subventricular zone neural stem cells (SVZ-NSCs) remains highly unknown. We aimed at studying how these modulators and their putative crosstalk impact OL differentiation from postnatal SVZ-NSCs. For this, C57BL/6 P1-3 mice SVZ-derived neurospheres were pharmacologically exposed to BDNF (30 ng/mL) and ZM 241385 (50 nM), an antagonist for A2ARs. mRNA expression levels of oligoden
ePoster · Neuroscience