SUMO2 conjugation rescues synaptic abnormalities in iPSC-derived neurons expressing mutant tau
Andrea Alloni, Franca Orsini, Lenzie K. Ford, Kenneth S. Kosik, Rajesh Soni, Ottavio Arancio, Paul E. Fraser, Luana Fioriti · FENS Forum 2024
SUMOylation is a covalent and reversible attachment of an 11 kDa SUMO (Small Ubiquitin-like MOdifier) protein to a lysine residue. SUMOylation act as a biochemical switch to regulate the function of hundreds of proteins in different pathways. In the brain of vertebrates, three main SUMO isoforms (SUMO1-3) are characterized. While SUMO2 and SUMO3 differ by only three N-terminal amino acids, they only share ~50% of their sequences with SUMO1. Global levels of SUMOylated proteins are altered in several neurodegenerative diseases; however, no data are currently available in Fronto-temporal dementi
ePoster · Neuroscience