Topic: sustained

Trait anxiety is a major risk factor for anxiety and stress-induced disorders in humans. However, animal models accounting for the inter-individual variability in stress vulnerability are largely lacking. Moreover, the pervasive bias of using mostly male animals in preclinical studies poorly reflects the increased prevalence of psychiatric disorders in women. Based on the threat imminence continuum theory, we designed and validated an auditory aversive conditioning-based pipeline in both female and male inbred mice. We operationalized trait anxiety by harnessing the naturally occurring variabi