Psychological stress regulation of acute-phase proteins through the hepatic sympathetic innervation
Eden Avishai, Hedva Haykin, Nadia Boshnak, Margarita Sirotkin, Zeinab Zbeidat, Tom Haran, Re'ee Yifa, Magen Sammons, Maria Krot, Tamar Koren, Itay Zalayat, Mariam Amer, Dorit Farfara, Hila Azulay-Debby, Eli Pikarsky, Asya Rolls · FENS Forum 2024
It is well-established that stress impairs immunity, however, the precise underlying mechanisms remain elusive. We discovered that stress modulates the expression levels of acute-phase proteins (APPs), which broadly regulate physiological processes including innate immunity and homeostasis maintenance. APPs are traditionally associated with the inflammatory response and are commonly used as indicators for inflammation (e.g., CRP). We found that stress on its own can also affect APPs levels and that stress preceding an inflammatory challenge disrupts the typical APPs response. Importantly, we f
ePoster · Neuroscience