Increased fear-related behaviors following alpha-synuclein preformed fibrils injected into the basolateral amygdala or striatum in mice
Thuy Lai, Wei Xiang, Christopher Käufer, Malte Feja, Kristina Lau, Friederike Zunke, Franziska Richter · FENS Forum 2024
Alpha-synuclein (αSyn)-related pathology crucially contributes to the pathogenesis of Parkinson’s disease (PD), leading to progressive neuronal populations loss in specific brain regions. This results in the presence of both motor and non-motor symptoms in PD patients. Anxiety occurs at an early stage of the disease and is one of the most frequent neuropsychiatric symptoms in patients with PD, indicating pathology in the cortico-limbic system. This study aimed to decipher that the spread of αSyn pathology to a given brain region is sufficient to induce non-motor symptoms observed in PD patient
ePoster · Neuroscience