Visualization of the intact cochlea and its architecture by newly refined light sheet fluorescence microscopy
Lennart Roos, Aleyna M. Diniz, Mostafa Aakthe, Anupriya Thirumalai, Koert Elisabeth, Jakob Neef, Bettina J. Wolf, Jan Huisken, Tobias Moser · FENS Forum 2024
According to the World Health Organization (WHO), a growing number of 0.5 billion people currently suffer from disabling hearing loss (HL). While causes of HL are diverse, it mainly originates in dysfunctions of the inner ear. Recent improvements in light sheet fluorescence microscopy allow nanometric examination of the whole intact cochlea in immunohistochemistry. These findings may help to identify and quantify disease mechanisms on a new scale and aid in the development of new treatment options for patients with severe HL. In this study, we assess the nano-architecture of the cochlea using
ePoster · Neuroscience