Topic: synapse-organizing proteins

Neurons communicate via synapses to allow normal brain functions such as cognition, memory formation, and learning. In these processes, synapses show plasticity and can be remodeled. Synapse formation is driven by synapse-organizing proteins that span the synaptic cleft to orchestrate the alignment of pre- and postsynaptic molecules. Recently, presynaptic α2δ proteins have been identified as crucial organizers of synapses by regulating axonal wiring, presynaptic differentiation, and postsynaptic receptor clustering. So far, α2δ proteins have been extensively studied as subunits of the voltage-