New insights into physiology of age-related cognitive disorders: The DNA repair protein ATR
Sabrina Briguglio, Clara Cambria, Benedetta Valentino, Giorgia Fattorini, Silvano Piazza, Giovanni Provenzano, Angelisa Frasca, Alessandra Folci, Flavia Antonucci · FENS Forum 2024
Aging is a multifactorial process characterized by the slow decline of cellular physiology associated with a lowdown of brain functions. Neurological complications mainly reflect defects at the synaptic structure. Indeed, preclinical studies demonstrate that preserving functionality of synapses delays the occurrence of aged-related neurological and cognitive defects and prevents the progressive neuronal degeneration. Since defects in DNA repair mechanisms have a critical role in aged-related neurological diseases and expression of core DNA repair genes is downregulated during aging across brai
ePoster · Neuroscience