Topic: synapse-resolution connectomes

The availability and scale of synapse-resolution connectomes containing the wiring of neural systems has grown rapidly in recent years. In order to exploit these rich datasets and extract neural circuit mechanisms underlying behavior, scalable connectome analysis tools capable of predicting information routing principles in circuit pathways are necessary. Current methods to extract neurons mediating information flow only consider a limited set of pathway lengths and do not scale to large connectome datasets. Here, we develop an efficient framework to identify such bottlenecks in pathways betwe