Role of HDAC4 in pre- and post-synaptic protein SUMOylation imbalance in a mouse model of Alzheimer’s disease
Claudia Colussi, Alessia Bertozzi, Giuseppe Aceto, Cristian Ripoli, Roberto Piacentini, Domenica Donatella Li Puma, Marcello D'Ascenzo, Claudio Grassi · FENS Forum 2024
Early dysfunction in Alzheimer's disease (AD) is characterized by abnormal synapse structure and function. We investigated the role of the class II member HDAC4, which controls synaptic plasticity and memory, as potential new modulator of synaptic function in AD. HDAC4 localization and function was assessed in hippocampal tissue from adult control (WT) and 3×Tg mice (AD) by confocal analyses, co-IP and biochemical fractioning. The effects of the overexpression of a cytoplasmic mutant form of HDAC4 (HDACSD) or the empty vector were analyzed in cultured hippocampal neurons or organotypic brain s