Behavioral regression in Syn II KO mice: From latent synaptopathy to overt dysfunctions in multisensory social processing
Lorenzo Ciano, Sebastian Sulis Sato, Alessandro Esposito, Anna Fassio, Fabio Benfenati, Caterina Michetti · FENS Forum 2024
Regression, understood as the loss of previously acquired behaviors, affects 20-30% of patients with Autism Spectrum Disorder (ASD). Nowadays, the mechanism behind this regressive process is still unknown. To improve our knowledge and find selected target treatments, it is important to establish a model with regressive features. Here, we showed that the Synapsin II Knockout (SynII KO) mouse loses previously acquired social and cognitive abilities in adulthood. Synapsin II is a presynaptic phosphoprotein belonging to the Synapsin family (Syns) involved in neuronal development and in the modulat
ePoster · Neuroscience