Synapsin role in presynaptic potentiation at hippocampal mossy fiber boutons
Felicitas Bruentgens, Laura Moreno Velasquez, Alexander Stumpf, Andrea Sannio, Dietmar Schmitz, Marta Orlando · FENS Forum 2024
Hippocampal mossy fiber boutons are giant, very plastic synapses that provide a strong and sparse input onto CA3 that is thought to be important for learning and memory. These synapses have a low basal release probability and display various forms of plasticity: frequency facilitation, post-tetanic potentiation (PTP), and a cAMP-dependent presynaptic form of long-term potentiation (LTP).Synapsins are the most abundant neuronal phosphoproteins. Due to their phosphorylation-dependent association with synaptic vesicles they play an important role in synaptic transmission and plasticity.Differentl
ePoster · Neuroscience