Using a targeted protein degradation technique to study synaptic compensation mechanisms countering synapse loss in Alzheimer’s disease
Ya Yin Chang, Patricio Opazo · FENS Forum 2024
Synapse loss is a key feature of many neurodegenerative diseases involving cognitive deficits, and is also the strongest correlate of cognitive decline in Alzheimer’s disease (AD). In addition, the integrity of dendritic spines, the post-synaptic sites of excitatory synapses, have been shown to play a key role in cognitive resilience against AD. Given the critical role of synaptic loss in cognitive decline, we hypothesized that synaptic compensation and repair play a vital role in counteracting synapse loss and as a consequence, in delaying the onset of cognitive deficits. The aim of our study
ePoster · Neuroscience