Interleukin-9 protects from microglia- and TNF-mediated synaptotoxicity in experimental multiple sclerosis
Alice Tartacca, Livia Guadalupi, Valentina Vanni, Sara Balletta, Silvia Caioli, Francesca De Vito, Diego Fresegna, Krizia Sanna, Monica Nencini, Elisabetta Volpe, Luca Battistini, Mario Stampanoni Bassi, Luana Gilio, Antonio Bruno, Ettore Dolcetti, Fabio Buttari, Georgia Mandolesi, Diego Centonze, Alessandra Musella · FENS Forum 2024
Background: Multiple sclerosis (MS) is a progressive neurodegenerative disease of the central nervous system characterized by inflammation-driven synaptic abnormalities. Interleukin 9 (IL-9) is emerging as a pleiotropic cytokine involved in MS pathophysiology.Aim: In this study, we demonstrated that both peripheral and central administration of IL-9 significantly improved clinical disability, reduced neuroinflammation, and mitigated synaptic damage in experimental autoimmune encephalomyelitis (EAE).Results: Biochemical, immunohistochemical, and electrophysiological experiments unmasked previou
ePoster · Neuroscience