Functional hemispheric asymmetry of medial habenula is associated with fear expression via modulation of GABAB receptor signaling in mice
Cihan Önal, Peter Koppensteiner, Elodie Le Monnier, Bernhard Bettler, Ryuichi Shigemoto · FENS Forum 2024
The habenula is a phylogenetically conserved bilateral brain structure known to modulate negative emotions. Hemispheric asymmetry in cortical areas plays a key role in behavior and cognition. Although habenular asymmetry is prominent in several vertebrate species, there is little evidence for left-right asymmetry in the mammalian habenula. To investigate the asymmetry in synaptic transmission in the medial habenula (MHb) to the interpeduncular nucleus (IPN) pathway in mice, we performed targeted electrical stimulation of left or right MHb-derived axons in acute slices. We discovered that the p
ePoster · Neuroscience