Rodent propionic acid model of autism: Emotional and ultrastructural changes in rat amygdala
Pikria Khomasuridze, Giorgi Lobzhanidze, Nadezhda Japaridze, Mzia Zhvania, Fuad Rzayev, Eldar Gasimov · FENS Forum 2024
Propionic acid (PA), a short-chain fatty acid and a metabolite of the gut microbiome, plays a significant role in health but has been associated with various pathologies, including autism spectrum disorder (ASD). Experimental studies in rodents have shown that elevated levels of PA can induce molecular and immune changes similar to those observed in ASD (MacFabe, et al.). However, limited knowledge exists regarding its impact on brain structural integrity. In this study, we examined the effects of a single intraperitoneal injection of PA at a dose of 175 mg/kg on adolescent male Wistar rats. S
ePoster · Neuroscience