Synaptic properties

…effects of acute stress on PFC synaptic properties, as well as on both the intrinsic and synaptic properties of PFC-basolateral amygdala (BLA) and PFC-PFC projection neurons. Adult male and female mice were exposed to either restraint stress (RS) or

In-silico simulations of neurons are crucial for understanding the complexinteractions and dynamics within neural networks, which underpin cognitivefunctions and behaviors in biological organisms. The Blue Brain Cellular Lab-oratory (BlueCelluLab) is a software package designed for detailed simulationand experimentation on individual and groups of neurons.Key features of BlueCelluLab include the ability to automate in-silico whole-cell patching experiments, offering a method for exploring neuron behavior in acontrolled, virtual setting. The software is effective in facilitating the validationo

…regulation, metabolic functions, and synaptic properties. Indeed, current research indicates that they play a pivotal role in several diseases.Previous published proteomic analyses show that several SLCs are frequently found in the membrane of extracellular vesicles (EVs) obtained from different bi

…reflecting uncertainty in neuronal and synaptic properties. We find that the connectome is often insufficient to constrain the dynamics of networks that perform a specific task, illustrating the difficulty

…However, the exact synaptic or neuron properties that modulate metaplasticity still remains unclear. In this work we use meta-continual learning to discover the importance of factors that contribute to metaplasticity. We use a linear model to assign the relative contribution of four commonly used synaptic properties to metaplasticity: the Hessian, gradient, magnitude of the weights, and activity of the post-synaptic neuron. The coefficients of the linear model ar