Microglial TREM2 receptor signaling shapes neuronal bioenergetics during development
Erica Tagliatti, Genni Desiato, Sara Mancinelli, Matteo Bizzotto, MariaCristina Gagliani, Elisa Faggiani, Rebeca Hernadez-Soto, Andrea Cugurra, Paola Poliseno, Matteo Miotto, Rafael J. Arguello, Fabia Filipello, Katia Cortese, Raffaella Morini, Simona Lodato, Michela Matteoli · FENS Forum 2024
Despite the traditional view of the brain as an immunological privileged organ, recent discoveries have revealed that a continuous crosstalk between microglia, the brain residential immune cells, and neurons is required for the maintenance of brain homeostasis and for the sculpting of neuronal connections during development. Indeed, defects in this bidirectional communication have been described in brain diseases, where altered microglia function, synaptic activity and plasticity may produce profound changes in nervous circuits and associated functions.The Triggering receptor expressed on myel
ePoster · Neuroscience