AutSim: Principled, data driven model development and abstraction for signaling in synaptic protein synthesis in Fragile X Syndrome (FXS) and healthy control.
Nisha Viswan,Upinder Bhalla · COSYNE 2022
Data provenance and model complexity are recurring challenges when simulating neural function, particularly signaling, at the level of detail needed to address disease conditions. Here we report a data-driven modeling and model abstraction framework applied to ~40 signaling pathways involved in translation and FXS. FXS is an X-linked neurodevelopmental disorder caused by the loss of FMRP which is an essential regulator for local translation at synapses. Bowling et al., 2019 had suggested that the de-novo translation profiles tend to differ in FXS mouse at steady-state and in the presence of mG
Sat, Mar 19, 2022