Ultrastructural analysis reveals mitochondrial placement independent of synapse placement in fine caliber C. elegans neurons
Danielle Riboul, Sarah Crill, Carlos Oliva, Maria Gabriela Restifo, Reggie Joseph, Kerdes Joseph, Ken Nguyen, David Hall, Yaouen Fily, Gregory Macleod · FENS Forum 2024
Neurons rely on mitochondria for an efficient supply of ATP and other metabolites. However, while neurons are highly elongated, mitochondria are discrete and limited in number. Due to the slow rates of diffusion over long distances it follows that neurons would benefit from an ability to control the distribution of mitochondria to sites of high metabolic activity, such as synapses. It is assumed that neurons’ possess this capacity, but ultrastructural data over substantial portions of a neuron’s extent that would allow for tests of such hypotheses are scarce. Here, we mined the Caenorhabditis
ePoster · Neuroscience