Topic: synaptosomal fraction

Aims: Autophagy is an evolutionary conserved process, that is very important in neurons. Neurons are post-mitotic cells which require a strict quality control mechanism to prevent accumulation of cellular debris and ensure nutrient and energy balance. Also synapses are key elements for healthy brain functioning. The synapses of neurons are highly dynamic, especially during early period of lifetimeand. Their rate increased during embryogenesis but subsequently unnecessary synapses are eliminated through a process called pruning modulated by autophagy. Many studies have shown that autophagy is a