Topic: Synaptotagmin-7

Besides its role in triggering fast neurotransmitter release, the protein Synaptotagmin-1 (Syt1) is also involved in the docking and priming process of synaptic vesicles (SVs) to the presynaptic active zone. Research indicates that Synaptotagmin-7 (Syt7) shares some functions with Syt1, but the specific mechanisms by which Syt7 exerts these functions are not well understood. To investigate the putative redundant role of Syt1/Syt7 in SV docking and priming we performed various experiments as high-pressure freezing and electron microscopy on hippocampal cultures, and electrophysiological recordi

Synaptic strength is dynamically modulated depending on prior activity called short-term synaptic plasticity (STP). STP is displayed as either or both by facilitation or depression. Facilitation of recurrent excitatory synapses within neocortical networks is proposed to have a critical role in working memory. However, facilitation in the prefrontal cortex (PFC), a key cortical area for working memory, remains unclear. We aimed to investigate the synaptic properties, including STP, at synapses of the rat PFC layer 2/3 network and made a vesicle dynamics model to describe these properties. We fo