Topic: synchronized network state

Cortical activity changes dramatically upon changes in behavioral state, such as between sleep versus wake (McGinley et al 2015). Though the mechanisms enabling these distinct modes of cortical operation remain largely unknown, inhibitory neurons (INs) have been suggested repeatedly as a regulator of behavioral-state dependent neocortical activity (Batista-Brito et al 2018, Cardin et al 2019, Bugeon et al 2021). Here we investigate how a unique subpopulation of long-range INs impact cortical states. These cells are defined by the co-expression of somatostatin (SST) and neuronal nitric oxide sy