Brain-state dependent deficit in visual discrimination in a mouse model of SYNGAP1-related intellectual disability and autism
Danai Katsanevaki, Nathalie Dupuy, Sam Booker, Nina Kudryashova, Damien Wright, Aisling Kenny, Zihao Chen, Pippa Howitt, Steffen Schneider, Mackenzie Mathis, Andrew Stanfield, Peter Kind, Nathalie Rochefort · FENS Forum 2024
Altered sensory experience is now considered a key feature of neurodevelopmental and autism spectrum disorders (ASD). This alteration results in, and often predicts, a range of cognitive, social, and behavioural affective impairments, strongly impacting the quality of life. However, the underlying neurophysiological mechanisms that disrupt sensory perception remain understudied. We investigated these mechanisms in a mouse model of SYNGAP1 haploinsufficiency (ΗΕΤ), SYNGAP1 being one of the most prevalent neurodevelopmental disorder genes. Using in vivo two-photon calcium imaging, we found that
ePoster · Neuroscience