Topic: α-synucleinopathy

Preclinical research into dementia with Lewy bodies (DLB) is challenging due to the lack of α-synucleinopathy animal models that do not also develop Parkinsonism. To address this issue, we have developed a new mouse model for investigating the impact of α-synuclein (α-Syn) overexpression and aggregation on driving cortical and hippocampal circuit dysfunction. Using bilateral stereotaxic injections of adeno-associated virus (AAVs) vectors, we transduced overexpression of human SNCA (encoding α-Syn) with mScarlet (red fluorophore), or an mScarlet-only control vector. We targeted either dorsal hi