ePoster · Neuroscience
Cell-type specific targeting of JNK inhibitor in brain using systemic AAVs elicits differential effects on affective behaviours in mice
Anniina Jokela, Nikita Tiwari, Jismi John, Prasannakumar Deshpande, Soroush Abyari, Eleanor Coffey · FENS Forum 2024
Upstream regulators on the c-Jun amino-terminal kinase (JNK) pathway are associated with neuropsychiatric disorders such as schizophrenia, bipolar, and autism. However, the mechanism of action of the JNK pathway in the context of these diseases is unknown. We previously identified that inhibition of JNK in dentate gyrus granule cells of mouse hippocampus induces a low anxiety- and low depressive-like phenotype (Mohammad et al., Molecular Psychiatry, 2018). However, whether JNK pathway activity in other brain regions contributes to these behaviours is not known. Here we use cell restrictive exp