Synergistic effect of melatonin and methylprednisolone on reducing disability in EAE by ameliorating induction, migration, and reactivation of T cells in the central nervous system
Ana Isabel Alvarez Lopez, Patricia Judith Lardone, Nuria Alvarez Sanchez, Ivan Cruz Chamorro, Guillermo Santos Sanchez, Eduardo Ponce España, Ignacio Bejarano, Antonio Carrillo Vico · FENS Forum 2024
Experimental autoimmune encephalomyelitis (EAE), the mouse model of multiple sclerosis, is triggered by myelin-specific T effector cells primed in peripheral lymph nodes that migrate to the central nervous system (CNS) where they are reactivated and induce demyelination. First-line treatment for disease relapses is a high dose of glucocorticoids for five consecutive days. Although melatonin ameliorates the severity of EAE by modulating T-cell responses, its action mechanism remains unclear. Our objective was to study the effects of melatonin on the peripheral priming of T cells, their migratio
ePoster · Neuroscience