Topic: T-cells

Spinal cord injury (SCI) in mammals leads to a series of cellular and molecular changes affecting self-repair. The breakdown of the blood-spinal cord barrier allows immune cells infiltration secreting various cytokines that, together with neural cells particularly activated microglia, will spread inflammation and aggravate the neurological deficits. Infiltrated immune cells include neutrophils, monocyte-derived macrophages, and T-cells. Most of preclinical studies evaluated this response in two SCI models: contusion (CT) and transection (TS); having distinct mechanical action modes on spinal c

Subarachnoid hemorrhage (SAH) triggers neuroinflammation including the recruitment and activation of immune cells. T-cells in particular, have been shown to promote the evolution of secondary injury following ischemic stroke, however their role in SAH is still unclear.In this study we aimed to evaluate T-cells’ recruitment in the brain of SAH-injured mice to next investigate their specific role in injury progression.Adult C57BL/6J mice were subjected to SAH by blood injection in the prechiasmatic cistern or sham procedure and sacrificed at 3 or 7 days-post-injury (dpi). Sensorimotor deficits w