Adenosine and astrocytes determine the developmental dynamics of spike timing-dependent plasticity in the somatosensory cortex
Irene Martinez-Gallego, Mikel Pérez-Rodríguez, Heriberto Coatl-Cuaya, Antonio Rodriguez-Moreno · FENS Forum 2024
During development, critical periods of synaptic plasticity facilitate the reordering and refinement of neural connections, allowing the definitive synaptic circuits responsible for correct adult physiology to be established. The L4-L2/3 synapses in the somatosensory cortex (S1) exhibit a presynaptic form of spike timing-dependent long-term depression (t-LTD) that probably fulfills a role in synaptic refinement. This t-LTD persists until the 4rd postnatal week in mice, disappearing thereafter. When we investigated the mechanisms underlying this maturation-related loss of t-LTD in mouse slices,
ePoster · Neuroscience