Topic: TACR3

Patients with tachykinin receptor 3 (TACR3) mutations experience pubertal failure, depression, and anxiety, but the underlying mechanisms are not fully understood. In this study, we found that rats with severe anxiety have reduced expression of TACR3 in the hippocampus. We also observed that TACR3 expression in the hippocampus increases in males during sexual development, parallel to changes in anxiety and serum testosterone levels. Although TACR3 is not highly expressed at synapses, its regulation significantly impacts synapse number, function, and plasticity. In particular, inhibiting TACR3