Electrophysiologic, transcriptomic, and morphologic plasticity of spinal inhibitory neurons to decipher atypical mechanosensory perception in Autism Spectrum Disorder
Anna Saint-Jean, Vanessa Rouglan, Florian Specque, Alexis Groppi, Macha Nikolski, Alexandre Favereaux, Yves Le Feuvre · FENS Forum 2024
Autism Spectrum Disorder (ASD) is characterized by impairments in social communication and interactions, as well as restricted behaviours. Strikingly most of ASD patients also exhibit aberrant reactivity to sensory stimuli including tactile stimuli. Tactile information is perceived in the periphery and processed in the spinal cord under the control of inhibitory neurons before being sent to higher brain structures. However, whether these inhibitory neurons undergo functional alterations in ASD models remains poorly investigated. To explore the functional plasticity of those neurons in ASD, we
ePoster · Neuroscience