The estrogen-immune axis: A key regulator of behavioural inflexibility
Mairead Sullivan, Sarita Dam, Angela Maria Ottomana, Martina Presta, Julia van Heck, Ilse Van de Vondervoort, Simone Macrì, Jeffrey C. Glennon · FENS Forum 2024
Aberrant insulin signalling was recently identified as a causative mechanism of Obsessive-Compulsive Disorder (OCD). Indeed, TALLYHO/JngJ mouse models of Type 2 diabetes are compulsive and anxious, with treatment with the Type 2 diabetes drug metformin generating partial rescue. Here, we aimed to establish the mechanisms behind this insulin-behavioural axis via proteomic analysis of brain and blood. Additionally, data from Genome-Wide Association studies (GWAS) of relevant disorders were compared using Ingenuity Pathway Analysis (IPA) (Qiagen). IPA analysis of proteomic results showed dysregul
ePoster · Neuroscience