Characterization of a new human co-culture model of endothelial cells, pericytes, and brain organoids in a microfluidic device
Anna Kocsis, Judit P. Vigh, Ana R. Santa-Maria, Nóra Kucsápszky, Silvia Bolognin, Jens C. Schwamborn, András Kincses, Anikó Szecskó, Szilvia Veszelka, Mária Mészáros, András Dér, Mára A. Deli, Fruzsina R. Walter · FENS Forum 2024
The blood-brain barrier (BBB) protects the brain and provides oxygen and nutrients for the central nervous system (CNS), but it also restricts the entry of pharmaceutical drugs into the brain. Cell culture models are essential to investigate cerebral drug delivery. Microfluidic chip devices allow complex and physiological modelling of the BBB. Induced pluripotent stem cell (iPSC) based technologies, the formation and use of human brain organoids provide simplified 3D modeling. Our aim was to (1) create and optimize a new, dynamic cell culture lab-on-a-chip model by the co-culture of a BBB mode
ePoster · Neuroscience