Topic: Targeted Recombination in Active Populations v2

Both classical activity mapping based on the induction of activity-regulated genes and novel genetic methods to label and control the activity of neurons indicate that memories are deposited in discrete neuronal ensembles in the hippocampus, amygdala and other brain regions involved in memory formation. However, the creation of a brain-wide map for engram formation and stability has proven to be a challenging endeavor that has been only partially solved. Among the methods to label active neurons, the Targeted Recombination in Active Populations v2 (TRAP2) mouse strain sticks out for enabling t