Type 1 transmembrane AMPA-receptor regulatory proteins are auxiliary subunits of Kv7.2 voltage-gated potassium channels
Marina Ventura Rodrigues, Ângela S. Inácio, Theo Bauberg, Maria V. Soldovieri, Telmo Leal, Sara Ribau, Luís Ribeiro, Nuno Beltrão, Gladys L. Caldeira, Laurent Groc, Joana I. Ferreira, Maurizio Taglialatela, Ana L. Carvalho · FENS Forum 2024
Seizures arise from disruption in mechanisms that control neuronal excitability and the M-current is one such mechanism. This low-threshold potassium current modulates neuronal excitability and suppresses repetitive firing. M-channels assemble as tetramers of Kv7 subunits and mutations in the KCNQ2 gene, encoding Kv7.2, are linked to epilepsy and intellectual disabilities. Despite this common epileptogenic mechanism, understanding M-channel regulation remains limited. We identified type 1 TARPs, well-known Transmembrane AMPA-receptors Regulatory proteins, as new interactors of the Kv7.2 subuni
ePoster · Neuroscience