Topic: task-relevant variables

The prefrontal cortex (PFC) plays an important role in cognitive processes such as working memory, but it is also involved in emotional and motivational processes such as anxiety and social interaction. Previous studies have shown that PFC neurons are modulated by different variables in one specific task, but it remains unclear how the same neurons respond during different tasks. Here we address this question by imaging the same PFC neurons in mice while they perform multiple tasks. We expressed the calcium indicator GCaMP6f in the medial PFC (mPFC) of C57BL/6N mice and implanted a GRIN lens t