Topic: Tau filaments

Spatial orientation deficits are emerging as very early and reliable cognitive biomarkers predicting future memory problems associated with Alzheimer’s disease, but the neural mechanisms underlying spatial disorientation have yet to be fully defined. The anterodorsal thalamic nucleus (ADn) contains a high density of head direction (HD) cells, which play a critical role in the brain's ability to create and update spatial representations, aiding in navigation and spatial memory. We propose that the accumulation of Tau filaments in cell bodies, dendrites, and axons of HD cells disrupts the proces