Functional interaction between traumatic brain injury and Alzheimer’s disease in next-gen humanized mice models
Amr Eed, Jake Hamilton, Xiaoyun Xu, Nicole Geremia, Corey A. Baron, Arthur Brown, Ravi S. Menon · FENS Forum 2024
Numerous studies have shown the involvement of Traumatic Brain Injury (TBI) in increasing the risk of developing dementia and Alzheimer’s Disease (AD) with age, yet the intricate details of how TBI could increase the risk of such afflictions remain obscure. The scarcity of research in this area can be attributed partially to the lack of suitable animal models that can carry humanized versions of the genes known to pose a risk for developing AD. We used two cohorts of 6 months old mice, each consisting of 10 animals (5 males), carrying humanized versions of Amyloid Precursor Protein (APP), Tau
ePoster · Neuroscience