The neuropathologic basis for translational biomarker development in the macaque model of late-onset Alzheimer’s disease
Caroline Zeiss, Anita Huttner, Alvaro Duque · FENS Forum 2024
Development of accurate biomarkers in the Alzheimer’s disease (AD) macaque model remains unattainable, in part because which aspects of macaque aging truly reflect comparable aspects of AD pathophysiology is unclear. To assess neuropathologic evidence underpinning biomarker development in macaques, we quantified ß-amyloid, pTau (AT8), neuroinflammatory marker and p16-expression in aging macaques (n=10) and AD patients (n=5). We assigned AD neuropathologic (ADNP) scores according to consensus guidelines. Further, we examined expression of pT217 and pT181 markers, acetylcholinesterase, tyrosine
ePoster · Neuroscience