ePoster · Neuroscience
Hippocampal representational drift and the impact of Alzheimer’s disease
Namra Aamir, Alexander Schmidt, Fred Wolf, Kotaro Mizuta, Yasunori Hayashi · Bernstein Conference 2024
The hippocampus (HC) plays a pivotal role in spatial navigation and memory in the human brain. Place cells, specialised neurons residing within the hippocampus, exhibit selective firing patterns corresponding to specific spatial locations, collectively contributing to the cognitive mapping of the environment. In healthy state, the place fields in the CA1 region exhibits continuous representational turnover [1]. Spatial navigation is disrupted in Alzheimer’s Disease (AD). AD, a neurodegenerative disorder characterised by progressive cognitive decline, is associated with deficits in learning a