Topic: Taupro-agg

Lewy body diseases (LBD) are complex neurodegenerative conditions that originate from an accumulation of misfolded alpha-synuclein (α-syn) often association with other proteins such as Amyloid β (Aβ), Tau, and TAR-DNA-binding protein. However, the nature of this association is poorly understood. To investigate the complex pathology of LBD, we constructed 2 novel transgenic overexpressing C. elegans models using human genes (α-synA53T;Taupro-agg and α-synA53T;Aβ1-42;Taupro-agg ). We then investigated the molecular, physiologic, and behavioral alterations of these and previously produced models.