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Topic: Taxol

ePoster
1 ePoster

In Neuroscience

AI-driven image analysis for label-free quantification of chemotherapeutic cytotoxicity in glial cells

Jasmine Trigg, Gillian Lovell, Daniel Porto, Nevine Holtz, Nicola Bevan, Tim Dale · FENS Forum 2024

Glioblastoma multiform is a malignant brain tumour associated with poor prognosis. To progress effective chemotherapies more advanced quantitative methods are required to provide insight into cytotoxicity in a non-perturbing manner. Here we demonstrate a robust live-cell imaging assay with label-free analysis to kinetically assess chemotherapeutic cytotoxicity in glial cells. We utilized the Incucyte® AI Cell Health Analysis Software Module which uses trained neural networks enabling label-free analysis of phase contrast images through accurate segmentation of individual cells and Live/Dead cl

ePoster · Neuroscience