Surface proteoprofiling of mechanosensing in brain endothelial cell health
Jacqueline Hammer, Dimitrios Spyropoulos, Bernd Wollscheid, Jan Wenzel · FENS Forum 2024
The cerebral capillary bed consists of a dense network of vessels out of specialized brain microvascular endothelial cells (BMECs) that deliver essential nutrients to the brain. To form functionally branched vasculature, BMECs have to sense and adapt to site-specific shear stress, relayed by mechanosensory cell surface proteins (CSPs) presented on the BMEC surface. Previous research on the effect of physiological and pathological shear stress on large vessels has studied unidirectional and oscillatory flow as proxies for laminar and disturbed shear stress. However, the effect of shear stress o
ePoster · Neuroscience