Case report: Assessment of progenitor and neuronal cell populations in a fetal case of hemimegalencephaly
Franziska Fazekas, Amit Haboosheh, Christof Worda, Julia Binder, Tina Linder, Anke Scharrer, Alexander Farr, Romana Höftberger, Ellen Gelpi, Gregor Kasprian, Christine Haberler, Nicole Amberg · FENS Forum 2024
The brain is comprised of a remarkable cell-type diversity, which arises during embryonic and fetal development from neural stem cells and provides the basis for proper brain function. Production errors in the tightly orchestrated process of brain development can result in neurodevelopmental malformations. Alterations in the mTOR pathway result in a spectrum of defects ranging from focal cortical dysplasia to hemimegalencephaly (HME). HME is a rare disorder, characterized by the enlargement of one hemisphere. To date, a detailed cellular and molecular understanding of the neuropathological und
ePoster · Neuroscience