Topic: TDP-43 nuclear localization

A key challenge in the study of amyotrophic lateral sclerosis (ALS) is that the affected cells, mainly motor neurons (MNs) and muscle cells (MCs), are difficult to isolate and work with in vitro. In this study, we aimed to investigate the pathological features of ALS using cultured dermal fibroblasts, whose isolation requires a minimally invasive biopsy. [SG1] Morphological and biochemical analyses revealed pronounced cytoplasmic buildup and aggregation of TAR DNA-binding protein 43 (TDP-43) in fibroblasts from ALS patients, reflecting alterations commonly observed in MNs. Moreover, transferri