Dysregulated lipid metabolism and neuroinflammation following high-fat diet in the TDP-43Q331K-low transgenic mouse model of ALS-FTD
Cortina Chen, Fredrick Arnold, Andrian Yang, Martin Giera, Albert La Spada, Florian Merkle · FENS Forum 2024
A combination of genetic and environmental factors likely underlies most neurodegenerative diseases. Among environmental factors, metabolic disease is an emerging risk factor, but the mechanisms that confer risk are still poorly understood. We hypothesise that diet-induced obesity dysregulates lipid metabolism and promotes glial activation in a mouse model of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). In particular, we aim to study the role of altered lipid metabolism and neuroinflammation in response to short (12 weeks) and prolonged (14-16 months) high-fat diet (H
ePoster · Neuroscience