Hippocampal replay events are impaired in a rat model of Fragile X Syndrome
Margaret Donahue, Emma Robson, Laura Colgin · FENS Forum 2024
Fragile X Syndrome (FXS) is a neurodevelopmental disorder that can cause impairments in spatial cognition. The hippocampus is thought to support spatial cognitive functions through the activity of place cells, neurons with spatial receptive fields. The reactivation or “replay” of previously active place cell sequences during sharp wave-ripples (SWRs) is believed to be important for spatial memory-guided planning and spatial memory consolidation. Previous research has shown that SWRs are abnormal in a mouse model of FXS (Boone et al. 2018), but to our knowledge the replay of place cell sequence
ePoster · Neuroscience