Topic: Temporal Order Memory

Spike timing relative to theta phase has been shown to mediate spatial and non-spatial information processing in medial temporal lobe (MTL) regions including hippocampus [1,2,3]. A prominent theory suggests that neural activity at different phases of theta oscillations encodes the serial order of items within short-term memory [4]. Based on recordings of spiking activity and local field potentials (LFPs) of epilepsy patients performing a multi-item sequential memory task, we show phase-dependent spiking during the delay, with preferred phases that were related to stimulus position within the s