The role of tenascin-C in the structural plasticity of perineuronal nets and synaptic expression in the murine hippocampus
Ana Jakovljevic, Vera Stamenković, Joko Poleksić, Igor Jakovcevski, Pavle R. Andjus · FENS Forum 2024
Neuronal plasticity is a fundamental property of the nervous system that allows a change in the response to stimulation by reorganizing its structure, functions and connections. Among the main regulators of neuronal plasticity are perineuronal nets (PNNs), condensed forms of extracellular matrix (ECM) that enwrap mainly parvalbumin expressing (PV+) inhibitory interneurons. Glycoprotein tenascin-C (TnC) is one of the ECM molecules that interacts with components of PNNs and that modulates the synaptic plasticity in the hippocampus. The aim of this study was to investigate whether TnC deficiency
ePoster · Neuroscience